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MBG 303 - Molecular Genetics I

Faculty of Engineering and Natural Sciences · Molecular Biology and Genetics (English 30%) · Undergraduate

ECTS: 5 T+P+L: 3+0+0 Compulsory
Coordinator: Dr. Öğr. Üyesi Mehmetali TİBATAN
Instructors: Dr. Öğr. Üyesi Mehmetali TİBATAN

Course Objective

1. To enable students to understand fundamental molecular genetic concepts.

2. To enable students to learn the structure of DNA and RNA.

3. To enable students to learn the concept of the central dogma and the 3D structures of proteins.

4. To enable students to understand different DNA types and their structural differences.

5. To explain in detail the stages from the codes in DNA to the protein synthesis process.

6. To enable students to interpret genetic diseases based on molecular genetic mechanisms.

 

Course Content

  1. Introduction To The Course
  2. Basics-Structure Of Nucleobases And Dna-Rna
  3. Different Forms Of Dna, End Of Dna Structure And Types Of Rnas
  4. Telomeric End Of Dna And Chromosomal Regulation Of Gene Functions
  5. Enzymes İnvolve İn Central Dogma
  6. Protein Structure
  7. Replication of DNA
  8. Gene Transcription And Rna Polymerase Function
  9. Protein Synthesis
  10. Transport Of Protiens And Mrna And Other Molecules
  11. Vesicular Transport
  12. Reviewing Of A Genetic Disorder

Explanations

Within the scope of  this course, students will acquire the fundamental knowledge to maintain and understand the topics covered in the second semester's Molecular II course by the end of the semester. It is one of the most essential and comprehensive courses in the Molecular Biology and Genetics department. Students are provied with detailed reviews throughout the semester and they are introduced  with other disciplines related to molecular genetics as general concept.

Rules

All students are required to attend 70% of the theoretical lectures and 80% of the laboratory lectures.
Students with a laboratory grade point average below 50 points will not be allowed to take the final exam.
The passing grade for the course is 50 points.
The allowed time for being late to class is the first 10 minutes.
The allowed time for being late to the exam is 20 minutes.
If anyone leaves the exam within the first 20 minutes, students who are late will not be admitted regardless of the 20-minute time limit.
Non-class activities (playing games, voice calls on the phone, texting on the phone, consuming strongly scented foods such as spices, garlic, and onions, personal hygiene, etc.) are prohibited during class.

Course Learning Outcomes

  1. Learn the structure and the functions of DNA and RNA
  2. Know the structure of the components of DNA and different forms of DNA (A, B, Z)
  3. Link between the DNA structure and the mutations
  4. Learn DNA replication, transcription and translation
  5. Have information about gene cloning
  6. Comprehend the recombinant DNA technology and the basics of genetic engineering

Core Area Distribution

(44) Physical Sciences%100

Teaching Methods

ExpressionQuestion-AnswerDiscussionExercise and PracticeSelf study

Assessment & Evaluation

Testing (Essay / Tests: True-Falls, multiple-choice, short answer, matching)

ECTS / Workload

ActivityQuantityDuration (h)Total Workload
Course Duration (Including Exam Week)16348
Out of Class Study Period16348
Midterm122
Quiz000
Assignment000
Practice000
Final122

Course Schedule

WeekSubjectPreparation
1Introduction To The CourseLesson materials will be shared
2Basics-Structure Of Nucleobases And Dna-RnaLesson materials will be shared
3Different Forms Of Dna, End Of Dna Structure And Types Of RnasLesson materials will be shared
4Telomeric End Of Dna And Chromosomal Regulation Of Gene FunctionsLesson materials will be shared
5Enzymes İnvolve İn Central DogmaLesson materials will be shared
6Central Dogma: Gene TranscriptionLesson materials will be shared
7Protein 3D StructureExersices for the exam
8MidtermExercises will be provided for the midterm exam
9DNA ReplicationLesson materials will be shared
10Protein TranslationLesson materials will be shared
11Molecular transport from the membranous structuresLesson materials will be shared
12Vesicular transportLesson materials will be shared
13Association between molecular transport and central dogmaLesson materials will be shared
14Reviewing a genetic diseaseLesson materials will be shared
15General review and exercises for the final examLesson materials will be shared
16Final ExaminationFinal Examination